Dosage and Administration. To give your dog Apoquel, you need to know the Apoquel dosing chart. During the study, dogs could not be treated with other drugs that could affect the assessment of effectiveness, such as corticosteroids, anti-histamines, or cyclosporine. But these side effects aren’t really painful, and they usually stop after the first few days of feeding. Apoquel (oclacitinib tablet) is a fast-acting anti-itch drug for used with canines. Always provide “Information for Dog Owners” Sheet with prescription.Use the lowest effective dose for the shortest duration consistent with individual response. The absolute bioavailability of oclacitinib maleate was 89%. Heartworm Treatment for Dogs. Inhibition of canine cytochrome P450 enzymes by oclacitinib is minimal; the inhibitory concentrations (IC50s) are 50 fold greater than the observed Cmax values at the use dose. APOQUEL safety speaks volumes. Apoquel is for use in dogs over 12 months in age and weighing more than 6.6 lbs. When treating pruritus associated with allergic dermatitis with oclacitinib, investigate and treat any underlying causes (e.g. The prandial state of dogs does not significantly affect the rate or extent of absorption. Select one or more newsletters to continue. To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet, contact Zoetis Inc. at 1-888-963-8471 or www.zoetis.com. Apoquel is sold per tablet or 100 count bottle in three strengths; Apoquel 3.6 mg tablet, Apoquel 5.4 mg tablet, and Apoquel 16 mg tablet. APOQUEL is safe to use in dogs 12 months of age or older. Adverse reactions reported (and percent of dogs affected) during Days 0-7 included diarrhea (2.3% APOQUEL, 0.9% placebo), vomiting (2.3% APOQUEL, 1.8% placebo), lethargy (1.8% APOQUEL, 1.4% placebo), anorexia (1.4% APOQUEL, 0% placebo), and polydipsia (1.4% APOQUEL, 0% placebo). The apparent mean (95% CL) volume of distribution at steady-state was 942 (870, 1014) mL/kg body weight. Dexmedetomidine-induced sedation occurred on each dosing day at all dose levels from 2 to 8 hours post-dosing. Heartworm: The Parasite. The dose of APOQUEL tablets is 0.18 to 0.27 mg/lb (0.4 to 0.6 mg/kg) APOQUEL should be given twice daily (BID) for up to 14 days of therapy and once daily (SID) thereafter for maintenance APOQUEL may be given with or without food APOQUEL may be discontinued without tapering During the three month recovery phase to this study, one oclacitinib maleate-treated dog (32-weeks old) was euthanized on Day 28 due to clinical signs which included enlarged prescapular lymph nodes, bilateral epiphora, lethargy, mild dyspnea, and fever. DOGS 540 lb 2.318.1 kg Draw full volume from ONE 1-mL vial as indicated. APOQUEL tablets contain 3.6 mg, 5.4 mg, or 16 mg of oclacitinib as oclacitinib maleate per tablet. APOQUEL is not for use in dogs less than 12 months of age (see Animal Safety). The dosage should be calculated in half tablet increments. CYTOPOINT ® provides long-lasting itch relief for dogs with allergic or atopic dermatitis. Clinical observations that were considered likely to be related to oclacitinib maleate included papillomas and a dose-dependent increase in the number and frequency of interdigital furunculosis (cysts) on one or more feet during the study. APOQUEL should be stored at controlled room temperature between 20° to 25°C (68° to 77°F) with excursions between 15° to 40°C (59° to 104°F). Glucocorticoids . Only the 20 mg and 60 mg tablets of GALLIPRANT are scored. For convenience, the dosing tables below may be used as a guideline. By Day 30, 86% (127/147) of the placebo group dogs and 15% (23/152) of the APOQUEL group dogs withdrew from the masked study because of worsening clinical signs, and had the option to enroll in an unmasked study and receive APOQUEL. ACVM No. Zoetis New Zealand Limited. Apoquel Dosage. For dogs that continued APOQUEL treatment beyond one week, the Veterinarian-assessed dermatitis scores continued to improve through study end at Day 30. The dosage will depends on your dog’s weight. Two dogs each developed an apocrine gland adenocarcinoma (one dermal, one anal sac) after approximately 210 and 320 days of APOQUEL administration, respectively. Dosing/Administration: The dose of Apoquel is 0.4-0.6 mg/kg every 12 hours for up to 14 days, then 0.4-0.6 mg/kg once daily thereafter. Two dogs each developed a Grade II mast cell tumor after 52 and 91 days of APOQUEL administration, respectively. Each strength tablets are packaged in 100 and 250 count bottles. Indicated for the treatment of pruritus associated with allergic dermatitis and the clinical manifestations of atopic dermatitis in dogs. So, there had to be side effects. One dog developed a moderately severe bronchopneumonia after 272 days of APOQUEL administration; this infection resolved with antimicrobial treatment and temporary discontinuation of APOQUEL. A double-masked, 30-day, controlled study was conducted at 26 U.S. veterinary hospitals. Each tablet is scored and marked with AQ and either an S, M, or L that correspond to the different tablet strengths on both sides. With that, you will be able to give them the right dosage. Following IV and PO administration, the terminal t1/2 appeared similar with mean values of 3.5 (2.2, 4.7) and 4.1 (3.1, 5.2) hours, respectively. APOQUEL is a registered trade mark of Zoetis Inc. or its subsidiaries. Dogs were randomized to treatment with APOQUEL (152 dogs: tablets administered at a dose of 0.4-0.6 mg/kg per dose twice daily for 14 days and then once daily) or placebo (147 dogs: vehicle control, tablets administered on the same schedule). The majority of dogs in the placebo group withdrew from the 112-day study by Day 16. Oclacitinib maleate was administered to healthy, one-year-old Beagle dogs twice daily for 6 weeks, followed by once daily for 20 weeks, at 0.6 mg/kg (1X maximum exposure dose, 8 dogs), 1.8 mg/kg (3X, 8 dogs), and 3.0 mg/kg (5X, 8 dogs) oclacitinib for 26 weeks. Apoquel is not FDA approved to use twice daily longer than 14 days. Apoquel Generic Name. Necropsy revealed pneumonia of short duration and evidence of chronic lymphadenitis of mesenteric lymph nodes. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Dogs on APOQUEL had decreased leukocytes (neutrophil, eosinophil, and monocyte counts) and serum globulin, and increased cholesterol and lipase compared to the placebo group but group means remained within the normal range. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Hemivertebrae are Congenitally Deformed Vertebra in Dogs and Cats. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. 14717 RVM; Available only under Veterinary Authorisation. For modified live canine parainfluenza virus (CPI), < 80% (6 of 8) of the dogs achieved adequate serologic response. Mean lymphocyte counts were transiently increased at Day 14 in the APOQUEL group. However, this is only applicable for the first 14 days. (3.6 kgs) cannot be accurately dosed. Dosage and treatment schedule The recommended initial dose is 0.4 to 0.6 mg oclacitinib/kg bodyweight, administered orally, twice daily for up to 14 days. In a masked field study to assess the effectiveness and safety of oclacitinib for the control of pruritus associated with allergic dermatitis in dogs, 216 dogs treated with APOQUEL and 220 dogs treated with placebo (vehicle control) were evaluated for safety. Necropsy revealed lesions consistent with sepsis secondary to immunosuppression. Beranda › apoquel dosing chart › apoquel dosing chart canada › apoquel dosing chart dogs › apoquel dosing chart kg › apoquel dosing chart noah. The typical dosage for Apoquel for dogs is 0.4–0.6 mg for every kilogram of body weight. Treatment success for each dog was defined as at least a 2 cm decrease from baseline on a 10 cm visual analog scale (VAS) in pruritus, assessed by the Owner, on at least 5 of the 7 evaluation days. Walmart.com. Mean time on this study was 372 days (range 1 to 610 days). In the 283 dogs that received APOQUEL, the following additional clinical signs were reported after beginning APOQUEL (percentage of dogs with at least one report of the clinical sign as a non-pre-existing finding): pyoderma (12.0%), non-specified dermal lumps (12.0%), otitis (9.9%), vomiting (9.2%), diarrhea (6.0%), histiocytoma (3.9%), cystitis (3.5%), anorexia (3.2%), lethargy (2.8%), yeast skin infections (2.5%), pododermatitis (2.5%), lipoma (2.1%), polydipsia (1.4%), lymphadenopathy (1.1%), nausea (1.1%), increased appetite (1.1%), aggression (1.1%), and weight loss (0.7). Clinical pathology findings considered to be oclacitinib maleate-related included mild, dose-dependent reduction in hemoglobin, hematocrit, and reticulocyte counts during the twice daily dosing period with decreases in the leukocyte subsets of lymphocytes, eosinophils, and basophils. Apoquel is an oral pill administered twice a day. For the first two weeks, this is to be given twice per day, and then once per day after the first two weeks for maintenance. Figure 1: Owner Assessed Pruritus VAS Scores by treatment for Days 0-7. endstream endobj 82 0 obj <>stream Total proteins were decreased over time primarily due to the albumin fraction. The chemical composition of APOQUEL is N-methyl[trans-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino) cyclohexyl]methanesulfonamide (2Z)-2-butenedioate. Mean (95% CL) total body oclacitinib clearance from plasma was low - 316 (237, 396) mL/h/kg body weight (5.3 mL/min/kg body weight). During the study, dogs could not be treated with other drugs that could affect the assessment of pruritus or dermal inflammation such as corticosteroids, anti-histamines, or cyclosporine. Note: Never give this medicine to your dog without the approval of your vet, and always follow the exact recommendations of your vet. Dogs receiving APOQUEL should be monitored for the development of infections, including demodicosis, and neoplasia. Shop WalmartPetRx.com for Apoquel Tablet and all of your other pet medications. When using the large syringe, the dog’s weight should be rounded down to the nearest 5-lb increment. Though trazodone has generally been shown to be beneficial and relatively safe for dogs, being aware of signs associated with serotonin syndrome is important as this can be a serious and potentially life-threatening condition to manage. Adverse reactions reported (and percent of dogs affected) during Days 0-16 included diarrhea (4.6% APOQUEL, 3.4% placebo), vomiting (3.9% APOQUEL, 4.1% placebo), anorexia (2.6% APOQUEL, 0% placebo), new cutaneous or subcutaneous lump (2.6% APOQUEL, 2.7% placebo), and lethargy (2.0% APOQUEL, 1.4% placebo). Between the masked and unmasked study, 283 dogs received at least one dose of APOQUEL. For dogs that continued APOQUEL treatment beyond one month, the mean Owner-assessed pruritus VAS scores and Veterinarian-assessed CADESI scores continued to improve through study end at Day 112. Apoquel dosing provides 3.6 mg, 5.4 mg, or 16 mg of oclacitinib per tablet, and each manufactured bottle is packaged with 20 counts or 100 counts of scored tablets. In case of accidental eye contact, flush immediately with water or saline for at least 15 minutes and then seek medical attention. Apoquel Dosing Chart. DOGS <5 lb <2.3 kg 0.09 mL/lb (0.2 mL/kg) drawn from ONE 10-mg vial. Five APOQUEL group dogs were withdrawn from study because of: darkening areas of skin and fur (1 dog); diarrhea (1 dog); fever, lethargy and cystitis (1 dog); an inflamed footpad and vomiting (1 dog); and diarrhea, vomiting, and lethargy (1 dog). Dogs in the APOQUEL group had a slight decrease in mean white blood cell counts (neutrophil, eosinophil, and monocyte counts) that remained within the normal reference range. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. One dog developed dermal pigmented viral plaques following 266 days of APOQUEL administration. While pet parents search for the root of the cause, Apoquel’s safe and effective treatment helps take the itch away so dogs can get back to their daily duties. One dog developed a low grade oral spindle cell sarcoma after 320 days of APOQUEL administration. According to the manufacturer’s dosage chart, a large breed weighing between 130 and 175lbs should take two Apoquel … Keep this and all drugs out of reach of children. Every effort has been made to ensure the accuracy of the Apoquel information published above. How is Apoquel Available? The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Apoquel tablets for dogs comes strengths of 3.6mg, 5.4 mg and 16mg of oclacitinib per tablet. Helicobacter Infection in Dogs and Cats. Veterinarians used a 10 cm VAS scale to assess each dog’s dermatitis. After the first 14 days, your vet might recommend you to reduce the dose to once every 24 hours. After one week of treatment, the mean Veterinarian-assessed VAS dermatitis score for the dogs in the APOQUEL group was lower at 2.2 cm (improved from a baseline value of 6.2 cm) compared with the placebo group mean score of 4.9 cm (from a baseline value of 6.2 cm). 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